Protein Details: G protein-activated inward rectifier potassium channel 3

Protein ID

ICDB_Pro_0553

Protein Name

G protein-activated inward rectifier potassium channel 3

Gene Name

Kcnj9; Girk3

Organism

Mus musculus (Mouse)

Length

393 amino acids

AlphaFoldDB

AF-P48543-F1-model_v4.pdb

Function

This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised; the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium

Sequence

MAQENAAFSPGSEEPPRRRGRQRYVEKDGRCNVQQGNVRETYRYLTDLFTTLVDLQWRLSLLFFVLAYALTWLFFGAIWWLIAYGRGDLEHLEDTAWTPCVNNLNGFVAAFLFSIETETTIGYGHRVITDQCPEGIVLLLLQAILGSMVNAFMVGCMFVKISQPNKRAATLVFSSHAVVSLRDGRLCLMFRVGDLRSSHIVEASIRAKLIRSRQTLEGEFIPLHQTDLSVGFDTGDDRLFLVSPLVISHEIDAASPFWEASRRALERDDFEIVVILEGMVEATGMTCQARSSYLVDEVLWGHRFTSVLTLEDGFYEVDYASFHETFEVPTPSCSARELAEAAARLDAHLYWSIPSRLDEKVEEEGAGEGAGAGDGADKEHNGCLPPPESESKV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed mainly in the brain; some expression in the skeletal muscle.

DOI ID

10.1016/0014-5793(94)01007-2; 10.1007/s002329900524; 10.1101/gr.2596504; 10.1016/j.cell.2010.12.001

RefSeq

NP_032455.2; XP_006496741.1